tcr repertoire importance for medical treatments

Prior to the expansion of NGS, the secrets of the immune system were probed by analyzing proteins however, protein-based diagnostic methods provide far less breadth and depth. Immune repertoire sequencing has unique advantages compared to the more common diagnostic and prognostic techniques that predate it. For a given patient, their immune repertoire may also be predictive of how they will respond to treatment or serve as a measure of treatment efficacy over time.Īt iRepertoire, we are deeply entrenched in the immunology field, and the technology we developed – from which our services are derived – was one of the first publications describing immune repertoire characterization with next generation sequencing (NGS). CDR3 sequencing can thus potentially be used for diagnosis. Immune profiles are clinically and diagnostically relevant because people with and without given diseases and with differing disease severity can exhibit distinct profile patterns.įor instance, specific disease prognoses can lead to the evolution of similar or identical CDR3s in different patients. The amount of diversity in the immune repertoire reflects the body’s ability to respond to disease. Why is immune repertoire sequencing important? Sequencing the expressed T and B cell receptor genes in the immune repertoire provides a detailed picture of a person’s health.What is the immune repertoire? In short, it is the collection of individual clonotypes produced by all B and T cells in the body.Jian Han, founder and CSO of iRepertoire Key questions: “Our immune system is the smartest and best doctor around, and if we can learn from the best, we can be better.” Dr.

Tcr repertoire importance for medical treatments